Product ID:A-59, ARSENIC TRIOXIDE SOLID
MSDS Date:04/05/1989
FSC:6810
NIIN:00-262-8576
MSDS Number: BPQRZ

FISHER SCIENTIFIC

1 REAGENT LANE
FAIR LAWN, NJ 07410
US

Emergency Phone: 201-796-7100;800-424-9300(CHEMTREC)

Info Phone: 201-796-7100

Cage: 1B464

FISHER SCIENTIFIC CO. CHEMICAL MFG DIV

FAIRLAWN, NJ 07410-2802 US

Telephone: 201-796-7100

Cage: 1B464

0.01 (AS) MG/M3; 2,

CAS: 1327-53-3

RTECS: CG3325000

Fraction By Weight: 100%

OSHA PEL SEE INGREDIENT NAME

ACGIH TLV: 0.2 (AS) MG/M3

EPA Report Quantity: 1 LB

DOT Report Quantity: 1 LB

CARD DISTURB, GEN PARAL,DEATH DUE TO CIRCULATORY

RTECS: 9999999ZZ

CHANGES, SKIN LESIONS,MEES LINES,EDEMA OF

RTECS: 9999999ZZ

ENCEPHALOPATHY, LIVER DMG,RENAL FAILURE, ANEMIA &

RTECS: 9999999ZZ

MAY CAUSE WEAK, HDCH, ANOREXIA, FATIGUE,

RTECS: 9999999ZZ

OCCAS VOMIT, DIARR, CONSTIPATION, CONJUNCT, CORYZA,

RTECS: 9999999ZZ

PERFORATION OF NASAL SEPTUM, ERYTHEMA, ECZEMA,

RTECS: 9999999ZZ

BRITTLE NAILS, WHITE BANDS ON NAILS,

RTECS: 9999999ZZ

PAIN, BURNING,& TENDERNESS. EFTS ON LIVER, KIDNEY,

RTECS: 9999999ZZ

MAY

RTECS: 9999999ZZ

MAY FOLLOW AFTER MANY YRS OF EXPOS. SKIN LESIONS MAY

RTECS: 9999999ZZ

RPTD/PRLNGD CONT MAY CAUSE EDEMA OF LIDS,CORNEAL

RTECS: 9999999ZZ

MAY CAUSE EFTS AS IN CHRONIC INHAL. OTHER SYMP INCL

RTECS: 9999999ZZ

ANXIETY, HOT FLUSHES, ATAXIA, MENTAL CONFUSN,EDEMA

RTECS: 9999999ZZ

LIVER EFTS,KIDNEY DMG. HEMATOLOGIC EFTS INCL

RTECS: 9999999ZZ

W/OUT SEV BLEEDING, DISTURBED ERYTHROPOIESIS,&

RTECS: 9999999ZZ

MYELOGENOUS LEUK HAS BEEN REPORTED. CARDIOVASCULAR

RTECS: 9999999ZZ

FAILURE AND GANGRENE OF EXTREMITIES. CANCER IN

RTECS: 9999999ZZ

(APPROX 15-20 MIN). GET MED ATTN IMMED.

RTECS: 9999999ZZ

OCCAS LIFTING UPPER/LOWER LIDS FOR AT LEAST 15

RTECS: 9999999ZZ

REMOVE BY GASTRIC LAVAGE/EMESIS. FOLLOW

RTECS: 9999999ZZ

O*2 IF RESP IS DEPRESS.DO NOT PERFORM GASTRIC

RTECS: 9999999ZZ

OF GASTRIC LAVAGE/O*2 SHD BE PERFORMED BY QUALIFIED

RTECS: 9999999ZZ

SPILL FOR LATER DISPOSAL. KEEP UNNECESSARY

RTECS: 9999999ZZ

LD50 LC50 Mixture:LD50: (ORAL,RAT) 40 MG/KG.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:YES OSHA:YES
Health Hazards Acute and Chronic:(ACUTE)INHAL: MAY CAUSE IRRIT OF RESP
TRACT W/COUGH, FOAMY SPUTUM, PAIN IN CHEST, DYSPNEA, & POSS PULM
EDEMA.CYANOSIS IN FACE, GIDDINESS, RESTLESSNESS, LASSITUDE, HDCH,
WEAK, HYPOTENSION, PAIN IN LIMB S, & LEUKOCYTOSIS. DELAYED GI SYMP
MAY INCL NAUS, VOMIT, COLIC & DIARR. SKIN: IRRIT SKIN W/ERYTHEMA,
(EFTS OF OVEREXP)
Explanation of Carcinogenicity:ARSENIC TRIOXIDE: GROUP 1 (IARC), KNOWN
CARCINOGEN (NTP), OSHA REGULATED
Effects of Overexposure:HLTH HAZ: ITCHING/BURNING. SENSIT DERM MAY
OCCUR IN PREVIOUSLY EXPOS PERSONS. SLIGHTLY ABSORB THRU SKIN WHEN
ADMIN IN LIPID VEHICLE. POIS HAS CAUSED ALOPECIA, BRONZING OF
SKIN,& BRITTLE NAILS, GASTRIT IS/GASTROENTERITIS. EYE: MAY CAUSE
IRRIT. INGEST: LETHAL DOSE IS 120 MG. SYMP MAY INCL BURNING & PAIN
IN CHEST, (SUPDAT)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

First Aid:INHAL: REMOVE TO FRESH AIR IMMED. IF BRTHG HAS STOPPED, GIVE
ARTF RESP. MAINTAIN AIRWAY & BLOOD PRESS & ADMIN O*2 IF AVAIL. KEEP
AFFECTED PERSON WARM/AT REST. TREAT SYMP & SUPPORTIVELY. ADMIN OF
O*2 S HD BE PERFORMED BY QUALIFIED PERS. GET MED ATTN IMMED. SKIN:
REMOVE CONTAM CLTHG & SHOES IMMED. WASH AFFECTED AREA W/SOAP/MILD
DETERGENT & LRG AMTS OF H*2O UNTIL NO EVIDENCE OF CHEM REMAINS (ING
19)

Extinguishing Media:DRY CHEMICAL, CARBON DIOXIDE, HALON, H*2O SPRAY/STD
FOAM. FOR LRGR FIRES, USE H*2O SPRAY, FOG OR STANDARD FOAM.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPRVD SCBA & FULL PROT
EQUIP.MOVE CNTNRS FROM FIRE AREA IF POSS. USE AGENTS SUITABLE FOR
TYPE OF FIRE, USE FLOODING AMTS OF H*2O (SUPDAT)
Unusual Fire/Explosion Hazard:NEGLIGIBLE FIRE HAZARD WHEN EXPOSED TO
HEAT OR FLAME.

Spill Release Procedures:DO NOT TOUCH SPILLED MATL. STOP LEAK IF YOU
CAN DO IT W/OUT RISK. TAKE UP W/SAND/OTHER ABSORB MATL & PLACE INTO
CNTNRS FOR DISP. W/CLEAN SHOVEL PLACE MATL INTO CLEAN, DRY CNTNR &
COVER. MOVE CNTNRS FR OM SPILL AREA. LRGR SPILLS: DIKE AHEAD OF
(ING 24)
Neutralizing Agent:AGRICULTURAL LIME, SLAKED LIME, CRUSHED LIMESTONE,
OR SODIUM BICARBONATE.

Handling and Storage Precautions:OBSERVE ALL FEDERAL, STATE AND LOCAL
REGULATIONS WHEN STORING OF SUBSTANCE. FOR ASSISTANCE, CONTACT
DISTRICT DIRECTOR OF ENVIRONMENTAL PROT AGENCY.
Other Precautions:SARA SEC 302 REQUIRES EACH FACILITY WHERE ANY
EXTREMELY HAZARDOUS SUBSTANCE IS PRESENT IN QTY EQUAL TO/> TPQ
ESTABLISHED FOR THAT SUBSTANCE NOTIFY STATE EMERGENCY RESPONSE
COMMISSION FOR STATE IN WHIC H IT IS LOCATED.

Respiratory Protection:WEAR NIOSH/MSHA APPROVED RESPIRATOR APPROPRIATE
FOR EXPOSURE OF CONCERN . FOR MORE SPECIFIC INFORMATION CONTACT
NEHC .
Ventilation:PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION TO
MEET PUBLISHED EXPOSURE LIMITS.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE
(IMPERVIOUS) CLTHG & EQUIPMENT TO PVNT RPTD/PRLNGD SKIN CONT
W/SUBSTANCE.
Work Hygienic Practices:CONTACT LENSES SHOULD NOT BE WORN.
Supplemental Safety and Health
FIRE FIGHT PROC: AS FOG. AVOID BRTHG POIS VAPS, KEEP UPWIND. EFTS OF
OVEREXP: ESOPHAGUS, STOMACH/BOWEL, CONSTRICTION IN THROAT,
DYSPHAGIA, WEAK, METALLIC TASTE, GASTROENTERITIS W/VOMIT, DIARR &
DEHYDR ATION, VERTIGO, HDCH, FEVER, RESTLESSNESS, CONFUS, DELIRIUM,
CYANOSIS, RAPID, FEEBLE PULSE, HYPOTENSION, SHOCK, (ING 2)

Boiling Pt:B.P. Text:869F,465C
Melt/Freeze Pt:M.P/F.P Text:594F,312C
Spec Gravity:3.738
Solubility in Water:3.7%
Appearance and Odor:WHITE, ODORLESS, TASTELESS CRYSTALLINE POWDER OR
AMORPHOUS OR VITREOUS CRYSTALS

Stability Indicator/Materials to Avoid:YES
ACIDS, AL, CLF*3, CU, F, HF, FE SOLUTIONS, HG, METALS, OF*2, NACL,
NANO*4, FESO*4, RUBIDIUM CARBIDE.
Stability Condition to Avoid:MAY BURN BUT DOES NOT IGNITE READILY.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY RELEASE
TOXIC OXIDES OF ARSENIC AND SODIUM AND HIGHLY TOXIC ARSINE GAS.

Waste Disposal Methods:OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS
WHEN DISPOSING OF SUBSTANCE. FOR ASSISTANCE, CONTACT DISTRICT
DIRECTOR OF ENVIRONMENTAL PROTECTION AGENCY.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.